One small step for muscle: a new micropeptide regulates performance

Cell Metab. 2015 Apr 7;21(4):515-6. doi: 10.1016/j.cmet.2015.03.013.


Micropeptides represent an emerging class of eukaryotic regulators that are easily missed in conventional genome annotation. Anderson et al. (2015) describe how a new tissue-specific micropeptide, myoregulin (MLN), interacts with the skeletal muscle calcium handling machinery to moderate contractile activity, representing a promising drug target for improving muscle performance.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Male
  • Muscle Proteins / genetics*
  • Muscle Proteins / metabolism*
  • Muscle, Skeletal / metabolism*
  • RNA, Long Noncoding / genetics*


  • Muscle Proteins
  • RNA, Long Noncoding