One small step for muscle: a new micropeptide regulates performance

Joanne Tonkin; Nadia Rosenthal

doi:10.1016/j.cmet.2015.03.013

One small step for muscle: a new micropeptide regulates performance

Cell Metab. 2015 Apr 7;21(4):515-6. doi: 10.1016/j.cmet.2015.03.013.

Authors

Joanne Tonkin¹, Nadia Rosenthal²

Affiliations

¹ National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK.
² National Heart and Lung Institute, Imperial Centre for Translational and Experimental Medicine, Imperial College London, London W12 0NN, UK; Australian Regenerative Medicine Institute/ EMBL Australia, Monash University, 3800 Melbourne, Australia. Electronic address: n.rosenthal@imperial.ac.uk.

PMID: 25863244
DOI: 10.1016/j.cmet.2015.03.013

Abstract

Micropeptides represent an emerging class of eukaryotic regulators that are easily missed in conventional genome annotation. Anderson et al. (2015) describe how a new tissue-specific micropeptide, myoregulin (MLN), interacts with the skeletal muscle calcium handling machinery to moderate contractile activity, representing a promising drug target for improving muscle performance.

Publication types

Comment

MeSH terms

Animals
Humans
Male
Muscle Proteins / genetics*
Muscle Proteins / metabolism*
Muscle, Skeletal / metabolism*
RNA, Long Noncoding / genetics*

Substances

Muscle Proteins
RNA, Long Noncoding