Antigen- And Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice

Cell Metab. 2015 Apr 7;21(4):543-57. doi: 10.1016/j.cmet.2015.03.005.

Abstract

A unique population of Foxp3(+)CD4(+) regulatory T (Treg) cells, with a distinct transcriptome and antigen-receptor repertoire, resides in visceral adipose tissue (VAT) of lean individuals. These cells regulate local inflammation and both local and systemic metabolic indices. Here we focus on expansion of the VAT Treg compartment in aging lean mice-assessing these cells' phenotypic conversion from conventional CD4(+) T cells, influx from lymphoid organs, and local population dynamics. Our findings establish that the VAT Treg compartment is seeded from thymocytes generated during the first weeks of life and expands beyond 10 weeks of age due to indolent proliferation, of certain clones in particular, coupled with enhanced survival. Accumulation of VAT Tregs depends on the antigen(s) presented by MHC class-II molecules and soluble mediators, notably interleukin(IL)-33. Addressing such factors therapeutically promises novel approaches for harnessing Tregs to stem the growing epidemic of obesity and consequent metabolic abnormalities.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • Cytokines / immunology*
  • Immunohistochemistry
  • Interleukin-33 / immunology
  • Intra-Abdominal Fat / cytology
  • Intra-Abdominal Fat / immunology*
  • Male
  • Mice
  • Models, Immunological*
  • Obesity / drug therapy
  • Obesity / immunology*
  • Thymocytes / immunology

Substances

  • Cytokines
  • Il33 protein, mouse
  • Interleukin-33