The association between LEPR Q223R polymorphisms and breast cancer risk

Breast Cancer Res Treat. 2015 May;151(1):1-6. doi: 10.1007/s10549-015-3375-6. Epub 2015 Apr 12.


Recently, we have read with great interest the article entitled "The association between polymorphisms in the leptin receptor (LEPR) gene and risk of breast cancer: a systematic review and pooled analysis" published online by Wang et al. (Breast Cancer Res Treat 136:231-239, 2012). This article suggests that the A allele of LEPR gene rs1137101 variant was low-penetrant risk factor for developing breast cancer. The result is encouraging. Nevertheless, several key issues are worth noticing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Breast Neoplasms*
  • Female
  • Genetic Association Studies*
  • Humans
  • Receptors, Leptin / genetics*


  • Receptors, Leptin