Plant derived and dietary phenolic antioxidants: anticancer properties

Food Chem. 2015 Sep 15;183:235-58. doi: 10.1016/j.foodchem.2015.03.039. Epub 2015 Mar 18.


In this paper, a review of the literature on the phenolic compounds with anticancer activity published between 2008 and 2012 is presented. In this overview only phenolic antioxidant compounds that display significant anticancer activity have been described. In the first part of this review, the oxidative and nitrosative stress relation with cancer are described. In the second part, the plant-derived food extracts, containing identified phenolic antioxidants, the phenolic antioxidants isolated from plants and plant-derived food or commercially available and the synthetic ones, along with the type of cancer and cells where they exert anticancer activity, are described and summarized in tables. The principal mechanisms for their anti-proliferative effects were also described. Finally, a critical analysis of the studies and directions for future research are included in the conclusion.

Keywords: Cancer; Dietary phenolic antioxidants; Synthetic phenolic antioxidants.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anticarcinogenic Agents / analysis*
  • Antioxidants / analysis*
  • Humans
  • Oxidation-Reduction
  • Phenols / analysis*
  • Plant Extracts / chemistry*
  • Plants, Edible / chemistry*


  • Anticarcinogenic Agents
  • Antioxidants
  • Phenols
  • Plant Extracts