Normal "high" thyroid stimulating hormone (TSH) levels and pregnancy rates in patients undergoing IVF with donor eggs

Clin Exp Obstet Gynecol. 2014;41(5):517-20.


Objective: To determine if a relationship exists between pregnancy rates obtained in patients undergoing in vitro fertilization (lVF) with donor eggs and levels of thyroid stimulating hormone greater than 2.5 mlU/L but still within a range considered normal.

Study design: Retrospective comparative cohort study. With prior approval of the Ethics Committee, 233 patients undergoing IVF with donor eggs, in a two-year period, were included. Patients were grouped depending on the thyroid stimulating hormone (TSH) level. Pregnancy rates were compared. Statistical analysis was made with the Chi-square test.

Results: Pregnancy rates, depending on the TSH level, were 56.6% in patients with TSH levels below 2.49 mU/L vs. 21.6%, in patients with levels above 2.5 mU/L. This difference was statistically significant (p < 0.001).

Conclusions: Mild abnormalities of thyroid function may adversely affect the pregnancy rates in patients un- dergoing in vitro fertilization with donor eggs. A possible alteration in endometrial function may be associated.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Biomarkers / blood
  • Female
  • Fertilization in Vitro / methods*
  • Follow-Up Studies
  • Gestational Age
  • Humans
  • Pregnancy
  • Pregnancy Rate / trends*
  • Retrospective Studies
  • Spain
  • Thyrotropin / blood*
  • Tissue and Organ Procurement / methods*
  • Young Adult


  • Biomarkers
  • Thyrotropin