Purpose: To evaluate whether ocular migraines can be related to sympathetic nervous system hypofunction, especially when associated with interstitial cystitis and dyspareunia.
Materials and methods: Dextroamphetamine sulfate was administered to a 34-year-old woman with a history of long-term interstitial cystitis, dyspareunia, and ocular migraines that were resistant to all other therapies.
Results: In a short length of time the sympathomimetic amine therapy almost completely abrogated all of her symptoms and they have remained controlled while she continues on the drug.
Conclusions: This is the first report of effectively treating ocular migraines with dextroamphetamine sulfate. The gynecologist should not be afraid to initiate therapy without referral to other specialists, especially if other symptoms of the sympathetic neural hyperalgesia edema syndromes exist, e.g., bladder pain of pelvic origin and dyspareunia.