Prognostic value of monocyte and neutrophils to lymphocytes ratio in patients with metastatic soft tissue sarcoma

Oncotarget. 2015 Apr 20;6(11):9542-50. doi: 10.18632/oncotarget.3283.


Metastatic soft tissue sarcomas (STS) represent enormous challenges to improve the low survival rate, which is almost the same as past 2 decades ago. Prognosis of cancer patients are based not only on tumor-related factors but also on host-related factors, particularly systemic inflammatory response. We evaluated the association among possible risk factors and survival for metastatic STS by reviewed a single-institution nearly 50-year experience. We found that both monocyte ratio and NLR ratio were significant prognostic predictors for OS and PFS of metastatic STS. And patients with monocyte ratio or NLR ratio > 1 should be screened out as candidates for more intensive or aggressive multimodality treatments and more aggressive follow-up. For this reason, this result could serve as a basis for future prospective study.

Keywords: immunity; metastasis; prognosis; soft tissue sarcoma.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Cell Count*
  • Child
  • Child, Preschool
  • Disease-Free Survival
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Lymphocyte Count
  • Male
  • Middle Aged
  • Monocytes*
  • Neutrophils*
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Sarcoma / blood
  • Sarcoma / mortality
  • Sarcoma / secondary*
  • Sarcoma / therapy
  • Young Adult