The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms

Biomed Res Int. 2015;2015:759348. doi: 10.1155/2015/759348. Epub 2015 Mar 19.

Abstract

P. aeruginosa is an opportunistic pathogenic bacterium responsible for both acute and chronic infections. Beyond its natural resistance to many drugs, its ability to form biofilm, a complex biological system, renders ineffective the clearance by immune defense systems and antibiotherapy. The objective of this report is to provide an overview (i) on P. aeruginosa biofilm lifestyle cycle, (ii) on the main key actors relevant in the regulation of biofilm formation by P. aeruginosa including QS systems, GacS/GacA and RetS/LadS two-component systems and C-di-GMP-dependent polysaccharides biosynthesis, and (iii) finally on reported natural and synthetic products that interfere with control mechanisms of biofilm formation by P. aeruginosa without affecting directly bacterial viability. Concluding remarks focus on perspectives to consider biofilm lifestyle as a target for eradication of resistant infections caused by P. aeruginosa.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Proteins / biosynthesis*
  • Bacterial Proteins / genetics
  • Biofilms / growth & development*
  • Drug Resistance, Bacterial / genetics
  • Gene Expression Regulation, Bacterial
  • Humans
  • Pseudomonas Infections / microbiology*
  • Pseudomonas Infections / pathology
  • Pseudomonas aeruginosa / genetics
  • Pseudomonas aeruginosa / growth & development*

Substances

  • Bacterial Proteins
  • GacA protein, Bacteria
  • RetS protein, Pseudomonas aeruginosa