Benefits and drawbacks of open partial horizontal laryngectomies, Part B: Intermediate and selected advanced stage laryngeal carcinoma

Head Neck. 2016 Apr;38 Suppl 1:E649-57. doi: 10.1002/hed.24064. Epub 2015 Jun 15.


Background: Cancer of the larynx in the intermediate/advanced stage still presents a major challenge in terms of controlling the disease and preserving the organ. Among therapeutic options, open partial horizontal laryngectomy is proposed as a function-sparing surgical technique.

Methods: We analyzed the clinical outcomes of 555 patients with laryngeal cancer staged pT3 to pT4a who underwent open partial horizontal laryngectomy.

Results: Five-year overall survival (OS), disease-free survival (DFS), locoregional control, local control, laryngectomy-free survival, and laryngeal function preservation rates were 84.6%, 84.2%, 86.3%, 90.6%, 93.3%, and 91.2%, respectively. DFS, locoregional control, and laryngeal function preservation rates were significantly affected by pT4a staging (68.1%, 71.7%, and 78.0%, respectively), whereas pN+ influenced only DFS (≤72.6%) and locoregional control (≤79.6%).

Conclusions: Open partial horizontal laryngectomy with a modular approach can be considered effective in terms of prognostic and functional results in intermediate-stage and selected advanced-stage laryngeal cancers, even with subglottic extension. © 2015 Wiley Periodicals, Inc. Head Neck 38: E649-E657, 2016.

Keywords: laryngeal cancer; laryngeal function-sparing protocol; open partial laryngectomy; supracricoid partial laryngectomy; supratracheal partial laryngectomy.

Publication types

  • Multicenter Study

MeSH terms

  • Aged
  • Carcinoma, Squamous Cell
  • Disease-Free Survival
  • Female
  • Humans
  • Laryngeal Neoplasms / surgery*
  • Laryngectomy / methods*
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Retrospective Studies
  • Survival Rate
  • Treatment Outcome