Single nucleotide polymorphism in the RECQL5 gene increased osteosarcoma susceptibility in a Chinese Han population

Genet Mol Res. 2015 Mar 13;14(1):1899-902. doi: 10.4238/2015.March.13.18.


In this study, we investigated the association between a RECQL genetic polymorphism and osteosarcoma in a Chinese population. We selected rs820196 in the RECQL5 gene and genotyped 185 patients with osteosarcoma and 201 age- and gender-matched non-cancer controls. We found that the CC genotype was more frequent in the osteosarcoma group compared to the control group (P = 0.011). We also found that the C allele was more common in osteosarcoma patients than that in control subjects (P = 0.004). Our results suggested that the RECQL5 genetic polymorphism was associated with osteosarcoma in a Chinese population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Asian People / genetics*
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease*
  • Genotyping Techniques
  • Haplotypes
  • Humans
  • Male
  • Osteosarcoma / genetics*
  • Polymorphism, Single Nucleotide*
  • RecQ Helicases / genetics*
  • Young Adult


  • RECQL5 protein, human
  • RecQ Helicases