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. 2015 Mar 30;37:e2015017.
doi: 10.4178/epih/e2015017. eCollection 2015.

Intestinal Obstruction: Predictor of Poor Prognosis in Colorectal Carcinoma?

Free PMC article

Intestinal Obstruction: Predictor of Poor Prognosis in Colorectal Carcinoma?

Mohd Azri Mohd Suan et al. Epidemiol Health. .
Free PMC article


Objectives: The goal of this study was to assess the relationship between intestinal obstruction and the prognosis of colorectal carcinoma.

Methods: Data pertaining to 4,501 colorectal carcinoma patients were extracted from the national colorectal registry and analysed. Survival analysis was performed using the Kaplan-Meier method. The log-rank test was used to compare the survival rate between patients with intestinal obstruction and those without intestinal obstruction. The p-values<0.05 were considered to indicate statistical significance. Simple Cox proportional hazards regression analysis was used to estimate the crude hazard ratio of mortality from colorectal cancer.

Results: Intestinal obstruction was reported in more than 13% of patients. The 3-year survival rate after treatment was 48.3% (95% confidence interval [CI], 43.9 to 52.8) for patients with intestinal obstruction (n=593) and 54.9% (95% CI, 53.1 to 56.6) for patients without intestinal obstruction (n=3,908). The 5-year survival rate for patients with intestinal obstruction was 37.3% (95% CI, 31.9 to 42.8), which was lower than that of patients without intestinal obstruction (45.6%; 95% CI, 43.5 to 47.7). After adjusting the hazard ratio for other prognostic variables, intestinal obstruction had a statistically significant negative correlation with the survival rate of colorectal cancer patients, with an adjusted hazard ratio of 1.22 (p=0.008).

Conclusions: The presence of intestinal obstruction is associated with a lower survival rate among colorectal cancer patients.

Keywords: Carcinoma; Colorectal neoplasm; Intestinal obstruction; Prognosis.

Conflict of interest statement

The authors have no conflicts of interest to declare for this study.


Figure 1.
Figure 1.
Kaplan-Meier curve of the survival of colorectal carcinoma patients with and without intestinal obstruction.

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