Motor cortex layer 4: less is more

Trends Neurosci. 2015 May;38(5):259-61. doi: 10.1016/j.tins.2015.03.005. Epub 2015 Apr 10.


The stratified motor cortex is variously thought to either lack or contain layer 4. Yamawaki et al. described a functional layer 4 in mouse motor cortex with properties and connections similar to layer 4 in sensory areas. Their results bolster a theoretical framework suggesting all primary cortical areas are equivalent.

MeSH terms

  • Animals
  • Humans
  • Motor Cortex / anatomy & histology*
  • Motor Cortex / physiology*