Click inspired synthesis of antileishmanial triazolyl O-benzylquercetin glycoconjugates

Pratibha Dwivedi; Kunj B Mishra; Bhuwan B Mishra; Nisha Singh; Rakesh K Singh; Vinod K Tiwari

doi:10.1007/s10719-015-9582-x

Click inspired synthesis of antileishmanial triazolyl O-benzylquercetin glycoconjugates

Glycoconj J. 2015 May;32(3-4):127-40. doi: 10.1007/s10719-015-9582-x. Epub 2015 Apr 14.

Authors

Pratibha Dwivedi¹, Kunj B Mishra, Bhuwan B Mishra, Nisha Singh, Rakesh K Singh, Vinod K Tiwari

Affiliation

¹ Department of Chemistry, Centre of Advanced Study, Faculty of Science, Banaras Hindu University, Varanasi, 221005, India.

PMID: 25869315
DOI: 10.1007/s10719-015-9582-x

Abstract

The 1,3-dipolar cycloaddition of deoxy-azido sugars 1 with O-benzylquercetin alkynes (5-7) to afford regioselective triazole-linked O-benzylquercetin glycoconjugates (8-10) was investigated in the presence of CuI/DIPEA in dichloromethane. All the developed glycoconjugates (8-10) were evaluated for anti-leishmanial activity against the promastigotes and amastigotes of Leishmania donovani. Graphical Abstract Click Inspired Synthesis of Antileishmanial Triazolyl O-Benzylquercetin Glycoconjugates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line / drug effects
Click Chemistry*
Drug Evaluation, Preclinical / methods
Leishmania donovani / drug effects
Macrophages / drug effects
Mice
Quercetin / chemistry*
Triazoles / chemical synthesis
Trypanocidal Agents / chemical synthesis*
Trypanocidal Agents / chemistry
Trypanocidal Agents / pharmacology*

Substances

Triazoles
Trypanocidal Agents
Quercetin