The potential of chitosan and its derivatives in prevention and treatment of age-related diseases

Mar Drugs. 2015 Apr 13;13(4):2158-82. doi: 10.3390/md13042158.


Age-related, diet-related and protein conformational diseases, such as atherosclerosis, diabetes mellitus, cancer, hypercholesterolemia, cardiovascular and neurodegenerative diseases are common in the elderly population. The potential of chitosan, chitooligosaccharides and their derivatives in prevention and treatment of age-related dysfunctions is reviewed and discussed in this paper. The influence of oxidative stress, low density lipoprotein oxidation, increase of tissue stiffness, protein conformational changes, aging-associated chronic inflammation and their pathobiological significance have been considered. The chitosan-based functional food also has been reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging*
  • Animals
  • Chitosan / analogs & derivatives*
  • Chitosan / metabolism
  • Chitosan / therapeutic use
  • Chronic Disease / prevention & control*
  • Chronic Disease / therapy
  • Dietary Supplements*
  • Foods, Specialized
  • Humans
  • Oligosaccharides / metabolism
  • Oligosaccharides / therapeutic use
  • Oxidative Stress


  • Oligosaccharides
  • Chitosan