Graphene-based protein biomarker detection

Bioanalysis. 2015;7(6):725-42. doi: 10.4155/bio.15.4.


An ability to detect and quantify protein molecules, harbingers of specific pathologies, potentially underpins both early disease diagnosis and an assessment of treatment efficacy. However, the specific detection of a particular protein biomarker in a complex environment is by no means an easy task and requires a progressive improvement in sensor technology. The high surface area, volume, electrical conductance, atomic level thickness and apparent biocompatibility of graphene makes it potentially an exceedingly powerful transducer of biorecognition events; the demands of its application in biosensing, and progress to date are reviewed herein.

Publication types

  • Review

MeSH terms

  • Biomarkers / analysis
  • Biomarkers / chemistry
  • Biosensing Techniques
  • Electrochemistry
  • Graphite* / chemistry
  • Proteins / analysis*
  • Proteins / chemistry
  • Transistors, Electronic


  • Biomarkers
  • Proteins
  • Graphite