The surprising activities of APOBEC3B and 5-fluorouracil

Biomed J. Mar-Apr 2015;38(2):97-100. doi: 10.4103/2319-4170.154913.

Abstract

In this mini-special issue on cancer, we learn how DNA editing enzymes can accelerate the development of cancer and we discover some remarkable effects of the chemotherapeutic agent, 5-fluorouracil, on the immune system. We also discuss a study revealing the continuing problem of vitamin B deficiencies in children in developing countries, and we determine how to distinguish two near-identical forms of necrotizing fasciitis.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cytidine Deaminase / genetics
  • Cytidine Deaminase / metabolism*
  • Fasciitis, Necrotizing / metabolism
  • Fluorouracil / pharmacology*
  • Humans
  • Minor Histocompatibility Antigens / genetics
  • Minor Histocompatibility Antigens / metabolism*
  • Mutation / genetics
  • Vitamins / metabolism

Substances

  • Minor Histocompatibility Antigens
  • Vitamins
  • APOBEC3B protein, human
  • Cytidine Deaminase
  • Fluorouracil