Abstract
3,5-Bis(trifluoromethyl)benzene modified bisbenzimide H 33258 was synthesized as a (19)F magnetic resonance-based DNA detection probe. The chemical shift and fluorescence of the probe were significantly changed by the addition of hairpin DNAs having an AATT sequence. The probe enables (19)F NMR/fluorescence bimodal detection of the model DNA double strands simultaneously.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bisbenzimidazole / analogs & derivatives*
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Bisbenzimidazole / chemical synthesis
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Bisbenzimidazole / chemistry*
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DNA / analysis*
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DNA Probes / chemical synthesis
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DNA Probes / chemistry*
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Fluorescence*
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HeLa Cells
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Humans
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Magnetic Resonance Spectroscopy
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Microscopy, Fluorescence
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Molecular Structure
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Toluene / analogs & derivatives*
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Toluene / chemistry
Substances
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DNA Probes
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Toluene
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DNA
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Bisbenzimidazole