EGFR-Mutated Breast Metastasis of Lung Adenocarcinoma: A Case Report

Case Rep Oncol. 2015 Mar 14;8(1):164-8. doi: 10.1159/000381014. eCollection 2015 Jan-Apr.

Abstract

Breast metastasis from other primary carcinoma is very rare and could be difficult to identify despite immunohistochemistry analysis. Breast metastasis from lung adenocarcinoma can mimic triple-negative breast cancer. Given the prognosis and therapeutic challenges, a correct diagnosis appears essential, and molecular biomarkers could be useful. We report the case of a 52-year-old woman with a breast mass initially diagnosed as primary breast cancer and secondarily attached to breast metastasis from an EGFR-mutated lung adenocarcinoma. The same activating EGFR mutations were identified in both the primary lung carcinoma and the breast metastasis.

Keywords: Breast metastasis; EGFR mutation; EGFR tyrosine kinase inhibitors; Lung adenocarcinoma; Triple-negative breast cancer.

Publication types

  • Case Reports