Histone deacetylases and atherosclerosis

Atherosclerosis. 2015 Jun;240(2):355-66. doi: 10.1016/j.atherosclerosis.2014.12.048. Epub 2014 Dec 23.

Abstract

Atherosclerosis is the most common pathological process that leads to cardiovascular diseases, a disease of large- and medium-sized arteries that is characterized by a formation of atherosclerotic plaques consisting of necrotic cores, calcified regions, accumulated modified lipids, smooth muscle cells (SMCs), endothelial cells, leukocytes, and foam cells. Recently, the question about how to suppress the occurrence of atherosclerosis and alleviate the progress of cardiovascular disease becomes the hot topic. Accumulating evidence suggests that histone deacetylases(HDACs) play crucial roles in arteriosclerosis. This review summarizes the effect of HDACs and HDAC inhibitors(HDACi) on the progress of atherosclerosis.

Keywords: Endothelial cells; HDACs; Macrophage cells; Plaque; Thrombosis; Vascular smooth muscle cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Arteries / drug effects
  • Arteries / enzymology*
  • Arteries / pathology
  • Atherosclerosis / diagnosis
  • Atherosclerosis / drug therapy
  • Atherosclerosis / enzymology*
  • Histone Deacetylase Inhibitors / therapeutic use
  • Histone Deacetylases / metabolism*
  • Humans
  • Necrosis
  • Plaque, Atherosclerotic
  • Signal Transduction
  • Vascular Calcification / enzymology

Substances

  • Histone Deacetylase Inhibitors
  • Histone Deacetylases