A resource for cell line authentication, annotation and quality control

Nature. 2015 Apr 16;520(7547):307-11. doi: 10.1038/nature14397.


Cell line misidentification, contamination and poor annotation affect scientific reproducibility. Here we outline simple measures to detect or avoid cross-contamination, present a framework for cell line annotation linked to short tandem repeat and single nucleotide polymorphism profiles, and provide a catalogue of synonymous cell lines. This resource will enable our community to eradicate the use of misidentified lines and generate credible cell-based data.

MeSH terms

  • Cell Line / classification*
  • Cell Line / metabolism*
  • Cell Separation
  • Data Curation*
  • Genotype
  • Guidelines as Topic*
  • Microsatellite Repeats / genetics
  • Polymorphism, Single Nucleotide / genetics
  • Quality Control
  • Reproducibility of Results
  • Species Specificity
  • Terminology as Topic

Associated data

  • BioProject/PRJNA271020