Pseudotumoral rebound of multiple sclerosis in a pregnant patient after stopping natalizumab

Mult Scler Relat Disord. 2014 Mar;3(2):279-81. doi: 10.1016/j.msard.2013.10.001. Epub 2013 Oct 3.


Natalizumab is a highly efficacious treatment for active relapsing-remitting multiple sclerosis, dramatically reducing both clinical and radiological signs of inflammation in most patients. The disease course after stopping treatment and especially the emergence of rebound activity are still a matter of debate. We present a case of dramatic reactivation of clinical disease activity with newly emerging pseudotumoral lesions in a patient who stopped treatment due to pregnancy. Both the clinical and radiological presentation suggest a rebound and necessitate close monitoring of patients stopping their treatment during pregnancy, even after a long period of stable disease.

Keywords: Multiple sclerosis; Natalizumab; Pregnancy; Pseudotumoral; Rebound.