Mimicking membrane-related biological events by DNA origami nanotechnology

ACS Nano. 2015 Apr 28;9(4):3418-20. doi: 10.1021/acsnano.5b01723. Epub 2015 Apr 16.

Abstract

One of the potential applications of DNA nanotechnology is the construction of two- or three-dimensional nanostructures that mimic the function of existing biological molecules. In this issue of ACS Nano, Kocabey et al. demonstrate that lipid-bilayer-anchored DNA origami structures can be assembled into prescribed superstructures in a programmed manner. The reported DNA-based artificial system can mimic the dynamic assembly of membrane-associated protein clusters that play an essential role in deformation of cellular membranes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cell Membrane / chemistry*
  • DNA / chemistry*
  • Nanostructures / chemistry*
  • Nanotechnology / methods*

Substances

  • DNA