Efficacy of orally administered fluralaner (Bravecto™) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs

Parasit Vectors. 2015 Mar 28;8:187. doi: 10.1186/s13071-015-0775-8.

Abstract

Background: This laboratory study compared the efficacy of Bravecto™ (fluralaner), formulated as a chewable tablet, with the efficacy of Advocate® (imidacloprid/moxidectin), formulated for topical administration, against naturally acquired generalized demodicosis in dogs.

Methods: Sixteen dogs, all diagnosed with generalized demodectic mange, were randomly allocated to two equal groups. Bravecto™ chewable tablets were administered once orally at a minimum dose of 25 mg fluralaner/kg body weight to one group of dogs, while the second group was treated topically on three occasions at 28-day intervals with Advocate® at a minimum dose of 10 mg imidacloprid/kg body weight and 2.5 mg moxidectin/kg body weight. Mites were counted in skin scrapings and demodectic lesions were evaluated on each dog before treatment and at 28-day intervals thereafter over a 12 week study period. Deep skin scrapings (~4 cm(2)) were made from the same five sites on each dog at each subsequent examination.

Results: After single oral administration of Bravecto™ chewable tablets, mite numbers in skin scrapings were reduced by 99.8% on Day 28 and by 100% on Days 56 and 84. Mite numbers in the dogs treated topically on three occasions at 28-day intervals with Advocate® were reduced by 98.0% on Day 28, by 96.5% on Day 56 and by 94.7% on Day 84. Statistically significantly (P ≤ 0.05) fewer mites were found on Days 56 and 84 on the Bravecto™ treated dogs compared to Advocate® treated dogs. A marked decrease was observed in the occurrence of erythematous patches, crusts, casts and scales in the dogs treated with Bravecto™ and in the occurrence of erythematous patches in the dogs treated with Advocate®. With the exception of one dog in each treated group, all dogs exhibited hair regrowth ≥ 90% at the end of the study in comparison with their hair-coat at study start.

Conclusions: Single oral administration of Bravecto™ chewable tablets is highly effective against generalized demodicosis, with no mites detectable at 56 and 84 days following treatment. In comparison, Advocate®, administered three times at 28-day intervals, is also highly effective against generalized demodicosis, but most dogs still harboured mites at all assessment time points. Both treatments resulted in a marked reduction of skin lesions and increase of hair re-growth 12 weeks after the initial treatment.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Animals
  • Dog Diseases / drug therapy
  • Dog Diseases / parasitology*
  • Dogs
  • Drug Combinations
  • Female
  • Imidazoles / administration & dosage
  • Imidazoles / therapeutic use*
  • Insecticides / administration & dosage
  • Insecticides / therapeutic use
  • Isoxazoles / therapeutic use*
  • Macrolides / administration & dosage
  • Macrolides / therapeutic use*
  • Male
  • Mite Infestations / drug therapy
  • Mite Infestations / veterinary*
  • Neonicotinoids
  • Nitro Compounds / administration & dosage
  • Nitro Compounds / therapeutic use*

Substances

  • A1443 compound
  • Drug Combinations
  • Imidazoles
  • Insecticides
  • Isoxazoles
  • Macrolides
  • Neonicotinoids
  • Nitro Compounds
  • imidacloprid
  • moxidectin