Developing medicines that mimic the natural successes of the human genome: lessons from NPC1L1, HMGCR, PCSK9, APOC3, and CETP

J Am Coll Cardiol. 2015 Apr 21;65(15):1562-6. doi: 10.1016/j.jacc.2015.02.049.

Author

Sekar Kathiresan¹

Affiliation

¹ Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; and the Broad Institute of MIT and Harvard, Cambridge, Massachusetts. Electronic address: skathiresan@partners.org.

PMID: 25881938
DOI: 10.1016/j.jacc.2015.02.049

No abstract available

Keywords: cholesterol; coronary disease; genetics; genetic association studies; human genome; medical; triglycerides.

Publication types

Editorial
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cholesterol, LDL / genetics*
Coronary Disease / genetics*
Female
Humans
Hydroxymethylglutaryl CoA Reductases / genetics*
Male
Membrane Proteins / genetics*
Polymorphism, Genetic*

Substances

Cholesterol, LDL
Membrane Proteins
Hydroxymethylglutaryl CoA Reductases