Runx2: Structure, function, and phosphorylation in osteoblast differentiation

Int J Biol Macromol. 2015;78:202-8. doi: 10.1016/j.ijbiomac.2015.04.008. Epub 2015 Apr 13.


Runx2 is a master transcription factor for osteogenesis. The most important phenomenon that makes this protein a master regulator for osteogenesis is its structural integrity. In response to various stimuli, the domains in Runx2 interact with several proteins and regulate a number of cellular events via posttranslational modifications. Hence, in this review we summarized the structural integrity of Runx2 and its posttranslational modifications, especially the phosphorylation responsible for either stimulation or inhibition of its regulatory role in osteogenesis.

Keywords: Bone; Osteoblast; Phosphorylation; Runx2.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Core Binding Factor Alpha 1 Subunit / chemistry*
  • Core Binding Factor Alpha 1 Subunit / physiology*
  • Gene Expression Regulation
  • Humans
  • Osteoblasts / cytology*
  • Osteoblasts / metabolism*
  • Phosphorylation
  • Structure-Activity Relationship


  • Core Binding Factor Alpha 1 Subunit