Targeting the sarcomere to correct muscle function

Nat Rev Drug Discov. 2015 May;14(5):313-28. doi: 10.1038/nrd4554. Epub 2015 Apr 17.


Various human diseases can disrupt the balance between muscle contraction and relaxation. Sarcomeric modulators can be used to readjust this balance either indirectly by intervening in signalling pathways or directly through interaction with the muscle proteins that control contraction. Such agents represent a novel approach to treating any condition in which striated muscle function is compromised, including heart failure, cardiomyopathies, skeletal myopathies and a wide range of neuromuscular conditions. Here, we review agents that modulate the mechanical function of the sarcomere, focusing on emerging compounds that target myosin or the troponin complex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiomyopathies / physiopathology
  • Cardiomyopathies / therapy
  • Heart Failure / physiopathology
  • Heart Failure / therapy
  • Humans
  • Muscle Contraction / physiology*
  • Muscle Proteins / metabolism
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / physiopathology
  • Muscular Diseases / physiopathology
  • Muscular Diseases / therapy*
  • Neuromuscular Diseases / physiopathology
  • Neuromuscular Diseases / therapy
  • Sarcomeres / metabolism*
  • Signal Transduction / physiology


  • Muscle Proteins