Bronchiolitis obliterans organising pneumonia in patients taking acebutolol or amiodarone

Thorax. 1989 Sep;44(9):711-5. doi: 10.1136/thx.44.9.711.


Two patients, treated with acebutolol and amiodarone respectively, developed a disease clinically, radiologically, and pathologically indistinguishable from bronchiolitis obliterans organising pneumonia. In one case recovery followed discontinuation of acebutolol; in the other case cessation of amiodarone had no effect, and corticosteroids were required. In addition to these patients, several cases of bronchiolitis obliterans organising pneumonia have been reported during treatment with gold salts, amiodarone, and miscellaneous other drugs. Taken together, this information supports the view that bronchiolitis obliterans organising pneumonia may be a form of response by the lungs to insult by drugs.

Publication types

  • Case Reports

MeSH terms

  • Acebutolol / adverse effects*
  • Aged
  • Aged, 80 and over
  • Amiodarone / adverse effects*
  • Biopsy
  • Bronchiolitis Obliterans / chemically induced*
  • Bronchiolitis Obliterans / pathology
  • Humans
  • Lung / pathology
  • Male
  • Middle Aged
  • Pneumonia / chemically induced*
  • Pneumonia / pathology


  • Acebutolol
  • Amiodarone