Infant botulism: review and clinical update

Pediatr Neurol. 2015 May;52(5):487-92. doi: 10.1016/j.pediatrneurol.2015.01.006. Epub 2015 Jan 21.


Botulism is a rare neuromuscular condition, and multiple clinical forms are recognized. Infant botulism was first identified in the 1970s, and it typically occurs in infants younger than 1 year of age who ingest Clostridium botulinum spores. A specific treatment for infant botulism, intravenous botulism immunoglobulin (BIG-IV or BabyBIG®), was developed in 2003, and this treatment has substantially decreased both morbidity and hospital costs associated with this illness. This article will review the pathogenesis of infant botulism as well as the epidemiology, clinical manifestations, diagnosis, and treatment of this condition.

Keywords: Clostridium; botulinum; botulism; infant; infantile; paralysis; review.

Publication types

  • Review

MeSH terms

  • Botulism / diagnosis*
  • Botulism / epidemiology
  • Botulism / therapy*
  • Humans
  • Immunoglobulins / therapeutic use*
  • Immunologic Factors / therapeutic use*
  • Infant


  • Immunoglobulins
  • Immunologic Factors
  • botulism immune globulin