Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis

Phytochemistry. 2015 Aug;116:253-261. doi: 10.1016/j.phytochem.2015.03.009. Epub 2015 Apr 13.


Seven lignans with a dibenzocyclooctadiene skeleton, termed schinlignans A-G, and a 6,7-seco-homolignan, schischinone, together with seven known lignans, were isolated from the fruits of Schisandra chinensis (Turcz.) Baill. Their structures were elucidated by extensive spectroscopic methods, including HRESIMS, IR, UV, and 2D NMR (COSY, HMQC, COSY, and HMBC experiments). The stereochemistry at the chiral centers and the biphenyl moiety, were determined using ROESY, as well as via interpretation of their ECD spectra. Schinlignan G and methylgomisin O exhibited potent anti-hepatitis B virus activity against HBV DNA replication with IC50 values of 5.13 and 5.49μgmL(-1), respectively.

Keywords: 6,7-Seco-homolignan; Dibenzocyclooctadiene lignans; Hepatitis B virus; Schisandra chinensis; Schisandraceae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology*
  • Cyclooctanes / chemistry
  • Cyclooctanes / isolation & purification*
  • Cyclooctanes / pharmacology*
  • Fruit / chemistry
  • Hepatitis B virus / drug effects*
  • Humans
  • Lignans / chemistry
  • Lignans / isolation & purification*
  • Lignans / pharmacology*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Schisandra / chemistry*


  • Antiviral Agents
  • Cyclooctanes
  • Lignans
  • dibenzocyclooctadiene
  • dibenzocyclooctadiene lignan