Potential role for targeted therapy in muscle-invasive bladder cancer: lessons from the cancer genome atlas and beyond

Urol Clin North Am. 2015 May;42(2):201-15, viii. doi: 10.1016/j.ucl.2015.01.003. Epub 2015 Mar 6.

Abstract

The Cancer Genome Atlas project has identified and confirmed several important molecular alterations that form the basis for tumorigenesis and disease progression in muscle-invasive bladder cancer. Profiling studies also have reported on validated biomarker panels that predict prognosis and may be used to identify patients who require more aggressive therapy. This article describes the major molecular alterations in muscle-invasive urothelial carcinoma, and how several of these are being investigated as targets for novel therapeutics. It also highlights studies that identify biomarkers for platinum sensitivity, and efforts to integrate targeted therapeutics and companion theranostics for personalized treatment of muscle-invasive bladder cancer.

Keywords: Clinical trials; Mutation analysis; Prognosis; Targeted therapy; Urothelial carcinoma; Whole-genome sequencing.

Publication types

  • Review

MeSH terms

  • Atlases as Topic
  • Genome, Human
  • Humans
  • Immunologic Factors / therapeutic use
  • Molecular Targeted Therapy*
  • Neoplasm Invasiveness
  • Protein Kinase Inhibitors / therapeutic use
  • Urinary Bladder Neoplasms / diagnosis
  • Urinary Bladder Neoplasms / genetics*
  • Urinary Bladder Neoplasms / therapy*

Substances

  • Immunologic Factors
  • Protein Kinase Inhibitors