Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 7 (6), 379-84

The Increased Cardiovascular Risk in Patients Affected by Autoimmune Diseases: Review of the Various Manifestations

Affiliations
Review

The Increased Cardiovascular Risk in Patients Affected by Autoimmune Diseases: Review of the Various Manifestations

Alessandro Durante et al. J Clin Med Res.

Abstract

Cardiovascular and autoimmune diseases are among major health concerns in developed countries, and both represent a significant source of morbidity, mortality and economic costs. Despite they are thought to affect subjects at different ages, most of the deaths of patients affected by autoimmune diseases are represented by cardiovascular deaths. Several manifestations of cardiovascular diseases can be observed in patients with autoimmune diseases, such as endothelial dysfunction, accelerated atherosclerosis and an increase in the rate of acute coronary syndromes. Thus, people with autoimmune diseases have an increased cardiovascular risk and a worse outcome in the case of cardiovascular events. In this review, we will describe the correlations between the two spectra of diseases.

Keywords: Atherosclerosis; Autoimmune diseases; CAD; Coronary microvascular dysfunction.

Similar articles

See all similar articles

Cited by 10 PubMed Central articles

See all "Cited by" articles

References

    1. Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev. 2003;2(3):119–125. doi: 10.1016/S1568-9972(03)00006-5. - DOI - PubMed
    1. Abou-Raya S, Abou-Raya A, Naim A, Abuelkheir H. Chronic inflammatory autoimmune disorders and atherosclerosis. Ann N Y Acad Sci. 2007;1107:56–67. doi: 10.1196/annals.1381.007. - DOI - PubMed
    1. Manzi S, Meilahn EN, Rairie JE, Conte CG, Medsger TA, Jr., Jansen-McWilliams L, D'Agostino RB. et al. Age-specific incidence rates of myocardial infarction and angina in women with systemic lupus erythematosus: comparison with the Framingham Study. Am J Epidemiol. 1997;145(5):408–415. doi: 10.1093/oxfordjournals.aje.a009122. - DOI - PubMed
    1. Fleming JN, Nash RA, Mahoney WM, Jr., Schwartz SM. Is scleroderma a vasculopathy? Curr Rheumatol Rep. 2009;11(2):103–110. doi: 10.1007/s11926-009-0015-3. - DOI - PMC - PubMed
    1. Ngian GS, Sahhar J, Wicks IP, Van Doornum S. Cardiovascular disease in systemic sclerosis--an emerging association? Arthritis Res Ther. 2011;13(4):237. doi: 10.1186/ar3445. - DOI - PMC - PubMed

LinkOut - more resources

Feedback