Interpretation of ileal biopsies

Indian J Pathol Microbiol. 2015 Apr-Jun;58(2):146-53. doi: 10.4103/0377-4929.155302.


The ileum is one of the most common sites of intestine to undergo endoscopic biopsy. However, even with the experienced histopathologists, a definite diagnosis can be achieved only in 18% cases. Lack of knowledge about proper tissue handling, tissue orientation, overlapping histological findings, and lack of a standard algorithm based approach results in this low diagnostic yield. In this review article, we have tried to discuss these aspects and give a clear picture how to approach the ileal lesions. It would help the surgical pathologists in effectively interpreting the lesions and to identify the common pitfalls.

Publication types

  • Review

MeSH terms

  • Biopsy*
  • Humans
  • Ileal Diseases / diagnosis*
  • Ileal Diseases / pathology*
  • Ileum / pathology*
  • Pathology / methods*