MicroRNAs: new biomarkers and therapeutic targets after cardiac arrest?

Crit Care. 2015 Feb 11;19(1):54. doi: 10.1186/s13054-015-0767-2.


Despite advances in resuscitation medicine, including target temperature management as part of post-cardiac arrest care, many patients will have a poor neurological outcome, most often resulting in death. It is a commonly held belief that the ability to prognosticate outcome at an early stage after cardiac arrest would allow subsequent health care delivery to be tailored to individual patients. However, currently available predictive methods and biomarkers lack sufficient accuracy and therefore cannot be generally recommended in clinical practice. MicroRNAs have recently emerged as potential biomarkers of cardiovascular diseases. While the biomarker value of microRNAs for myocardial infarction or heart failure has been extensively studied, less attention has been devoted to their prognostic value after cardiac arrest. This review highlights the recent discoveries suggesting that microRNAs may be useful both to predict outcome and to treat patients after cardiac arrest.

Trial registration: ClinicalTrials.gov NCT01020916.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / blood*
  • Cardiopulmonary Resuscitation
  • Critical Care
  • Heart Arrest / blood*
  • Heart Arrest / therapy
  • Humans
  • Hypothermia, Induced
  • MicroRNAs / blood*
  • Prognosis


  • Biomarkers
  • MicroRNAs

Associated data

  • ClinicalTrials.gov/NCT01020916