Cobalamin-dependent enzymatic O-, N-, and S-demethylation

Trends Biotechnol. 2015 Jul;33(7):371-3. doi: 10.1016/j.tibtech.2015.03.011. Epub 2015 Apr 14.

Abstract

Cobalamine cofactors (vitamin B12) are complex organometallic molecules that are crucial for the activity of a variety of different interesting enzymes such as isomerases, methyltransferases, and dehalogenases. Developments in understanding the structure, mechanism, and role in nature of methylcobalamin-dependent methyltransferases make them excellent candidates for biotechnological applications such as biocatalytic dealkylation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biotechnology*
  • Methylation
  • Methyltransferases*
  • Vitamin B 12*

Substances

  • Methyltransferases
  • Vitamin B 12