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Dysregulation of Over-Expressed IL-32 in Colorectal Cancer Induces Metastasis


Dysregulation of Over-Expressed IL-32 in Colorectal Cancer Induces Metastasis

Yi Yang et al. World J Surg Oncol.


Background: Interleukin (IL)-32 is a described intracellular pluripotent pro-inflammatory mediator, characterized by the signaling of NF-κB and STAT3.

Methods: Our study investigated whether IL-32 expression has clinical significance in the metastases of colorectal cancer (CRC). A total of 70 CRC patients were enrolled, 47 cases of which were single CRC organic metastasis lesions while the rest of which were primary CRC lesions (T4NxM0). IL-32 expression was detected by immunohistochemistry, and the correlation between IL-32 expression and CRC metastases was analyzed.

Results: The positive rates of IL-32 in the CRC organic metastasis group were more severe than those in the primary CRC group (P < 0.05). The positive rate of IL-32 in primary CRC with lymph node metastasis was more severe than that of IL-32 in primary CRC without lymph node metastasis (P < 0.05).

Conclusions: The level of IL-32 expression could influence the N grade of CRC. Thus, IL-32 expression may stimulate the organic metastasis and the lymph node metastasis of CRC.


Figure 1
Figure 1
IL-32 staining scored 0 (A); IL-32 staining scored 1+ (B); IL-32 staining scored 2+ (C); and IL-32 staining scored 3+ (D) magnification × 100.
Figure 2
Figure 2
The relationship between N grade of primary CRC and OD value.

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