High-resolution imaging of the central nervous system: how novel imaging methods combined with navigation strategies will advance patient care

Prog Brain Res. 2015:218:55-78. doi: 10.1016/bs.pbr.2014.12.011. Epub 2015 Mar 14.


This narrative review captures a subset of recent advances in imaging of the central nervous system. First, we focus on improvements in the spatial and temporal profile afforded by optical coherence tomography, fluorescence-guided surgery, and Coherent Anti-Stokes Raman Scattering Microscopy. Next, we highlight advances in the generation and uses of imaging-based atlases and discuss how this will be applied to specific clinical situations. To conclude, we discuss how these and other imaging tools will be combined with neuronavigation techniques to guide surgeons in the operating room. Collectively, this work aims to highlight emerging biomedical imaging strategies that hold potential to be a valuable tool for both clinicians and researchers in the years to come.

Keywords: central nervous system imaging; human imaging atlas; magnetic resonance imaging; neuronavigation; optical coherence tomography.

Publication types

  • Review

MeSH terms

  • Anatomy, Artistic
  • Atlases as Topic
  • Central Nervous System / anatomy & histology*
  • Central Nervous System / surgery
  • Diagnostic Imaging / methods*
  • Humans
  • Optical Imaging
  • Patient Care / instrumentation*
  • Patient Care / methods
  • Spectrum Analysis, Raman
  • Tomography, Optical Coherence