Establishment of a human glioma cell line bearing a homogeneously staining chromosomal region and releasing alpha- and beta-type transforming growth factors

Acta Neuropathol. 1989;79(1):30-6. doi: 10.1007/BF00308954.


A human glioma cell line (YKG1), which was positively identified for glial fibrillary acidic (GFA) and S-100 proteins, was established from a surgical specimen of a patient with glioblastoma. Chromosome analysis of the cells revealed a homogeneously staining region (HSR) on a marker chromosome. The assay for transforming growth factors (TGFs) in the conditioned medium of the cell line revealed that it contained high levels of alpha- and beta-type TGFs, which might regulate the growth of glioblastoma and influence on the peritumoral tissues.

Publication types

  • Case Reports

MeSH terms

  • Cell Line
  • DNA, Neoplasm / analysis*
  • Female
  • Glioma / genetics*
  • Humans
  • Middle Aged
  • Transforming Growth Factors / genetics*
  • Tumor Cells, Cultured / cytology*


  • DNA, Neoplasm
  • Transforming Growth Factors