Tolerance to morphine induced by chronic mild environmental stressors

Acta Physiol Hung. 1989;73(4):447-53.


Pain-sensitivity as well as the analgesic and thermoregulatory effects of morphine were studied after two different types of chronic environmental stresses in rats (extra stimulation of newborns for 21 days, or social isolation for a month in adult age). The basal pain sensitivity and the base-line body temperature were similarly affected after the two interventions: an increased tail-flick latency, a decreased hot-plate latency and a decreased body temperature were noted. The analgesic and thermoregulatory effects of morphine were uniformly reduced in rats exposed to either stress. These findings suggest a common effect of various non painful mild environmental stresses on the activity of the endogenous opioid system.

MeSH terms

  • Animals
  • Animals, Newborn
  • Body Temperature Regulation / drug effects
  • Body Temperature Regulation / physiology
  • Drug Tolerance / physiology
  • Male
  • Morphine / pharmacology*
  • Pain Measurement
  • Rats
  • Rats, Inbred Strains
  • Stress, Psychological / physiopathology


  • Morphine