Hormone replacement therapy and longevity

Andrologia. 2016 Feb;48(1):65-8. doi: 10.1111/and.12419. Epub 2015 Apr 19.


To assess whether hormone replacement therapy influences longevity, an analysis was made of published life tables allowing for the calculation of the relative benefit of hormone replacement therapy on longevity in men with late onset hypogonadism and in post-menopausal women. It was found that testosterone replacement therapy of men suffering from late onset hypogonadism increased survival rate by 9-10% in 5 years, similar to that of eugonadal, non-LOH men with normal endogenous testosterone secretion. Oestrogen replacement therapy resulted in increased survival by 2.6% in 5 years. It is concluded that hormone replacement therapy increases longevity.

Keywords: Ageing; hormones; longevity; oestrogen therapy; testosterone therapy.

MeSH terms

  • Androgens / therapeutic use*
  • Cohort Studies
  • Estrogen Replacement Therapy / methods*
  • Female
  • Hormone Replacement Therapy / methods
  • Humans
  • Hypogonadism / drug therapy*
  • Kaplan-Meier Estimate
  • Late Onset Disorders / drug therapy
  • Life Tables*
  • Longevity*
  • Male
  • Postmenopause
  • Testosterone / therapeutic use*


  • Androgens
  • Testosterone