Evaluation of palatal donor site haemostasis and wound healing after free gingival graft surgery

J Clin Periodontol. 2015 Jun;42(6):582-9. doi: 10.1111/jcpe.12404. Epub 2015 May 19.


Aim: Evaluating effectiveness of a medicinal plant extract (MPE) in achieving haemostasis and early wound healing at free gingival graft (FGG) donor site in a randomized controlled fashion.

Methods: Forty patients requiring FGG at lower anterior area were randomly assigned into two groups. FGG was performed to all patients and following graft procurement; wet gauze (WG) was applied alone (control: WG group) or with MPE (test: MPE + WG group) for haemostasis. Donor site working time, bleeding (BLE), colour match (CM), pain, epithelization (EP) and sensation loss (SL) were evaluated.

Results: Thirty-three participants completed a 6-month period study. In the test group, primary BLE was shorter (p < 0.001) and fewer individuals showed secondary BLE during 3 days (p < 0.001). During the 6 days, pain scores were higher in WG patients (p < 0.05). Later on, no inter-group difference was observed. EP was relatively faster (p < 0.001) and CM was slightly better (p < 0.05) in MPE + WG group.

Conclusion: MPE provided faster and continuous haemostasis that made a positive contribution to the early soft tissue healing to some extent but due to limitations; further trials are needed to demonstrate the efficiency of this material.

Keywords: donor site; free gingival graft; haemostasis; palatal healing; wound healing.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Loss, Surgical
  • Color
  • Female
  • Follow-Up Studies
  • Free Tissue Flaps / transplantation*
  • Gingiva / transplantation*
  • Gingivoplasty / methods
  • Hemostatics / therapeutic use*
  • Humans
  • Male
  • Operative Time
  • Oral Hemorrhage / etiology
  • Pain Measurement / methods
  • Pain, Postoperative / etiology
  • Palate / surgery*
  • Phytotherapy / methods*
  • Plant Extracts / therapeutic use*
  • Plants, Medicinal*
  • Prospective Studies
  • Re-Epithelialization / physiology
  • Sensation / physiology
  • Transplant Donor Site / surgery*
  • Wound Healing / physiology
  • Young Adult


  • Hemostatics
  • Plant Extracts
  • ankaferd blood stopper