Reduced default mode network connectivity in schizophrenia patients

Anne Pankow; Lorenz Deserno; Martin Walter; Thomas Fydrich; Felix Bermpohl; Florian Schlagenhauf; Andreas Heinz

doi:10.1016/j.schres.2015.03.027

Reduced default mode network connectivity in schizophrenia patients

Schizophr Res. 2015 Jun;165(1):90-3. doi: 10.1016/j.schres.2015.03.027. Epub 2015 Apr 16.

Authors

Anne Pankow¹, Lorenz Deserno², Martin Walter³, Thomas Fydrich⁴, Felix Bermpohl⁵, Florian Schlagenhauf⁶, Andreas Heinz⁵

Affiliations

¹ Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité, Universitätsmedizin Berlin, Germany. Electronic address: anne.pankow@charite.de.
² Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité, Universitätsmedizin Berlin, Germany; Max Planck Fellow Group 'Cognitive and Affective Control of Behavioral Adaption', Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; Department of Neurology, Otto von Guericke University, Magdeburg, Germany.
³ Department of Neurology, Otto von Guericke University, Magdeburg, Germany; Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany; Leibniz Institute for Neurobioloy, Magdeburg, Germany.
⁴ Department of Psychology, Humboldt-Universität zu Berlin, Germany.
⁵ Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité, Universitätsmedizin Berlin, Germany.
⁶ Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité, Universitätsmedizin Berlin, Germany; Max Planck Fellow Group 'Cognitive and Affective Control of Behavioral Adaption', Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

PMID: 25892719
DOI: 10.1016/j.schres.2015.03.027

Abstract

In the present study, we explored possible alterations in the default mode network (DMN) and its functional connectivity in 41 schizophrenia patients and 42 age-matched healthy controls. Schizophrenia patients displayed reduced activation in the ventromedial prefrontal cortex, left superior temporal gyrus including auditory cortex and temporal pole. Psychophysiological interaction analysis revealed reduced connectivity between left superior temporal gyrus including auditory cortex and the left temporal pole in schizophrenia patients compared to healthy subjects.

Keywords: Default mode network; Functional imaging; Schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antipsychotic Agents / therapeutic use
Case-Control Studies
Cerebral Cortex / blood supply
Cerebral Cortex / pathology*
Female
Functional Laterality / physiology
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Nerve Net / blood supply
Nerve Net / physiopathology*
Neural Pathways / blood supply
Neural Pathways / physiopathology*
Oxygen / blood
Psychophysics
Schizophrenia / drug therapy
Schizophrenia / pathology*

Substances

Antipsychotic Agents
Oxygen