Treatment of atopic dermatitis with KAM-3008, a barrier-based, non-steroidal topical cream

J Dermatolog Treat. 2015 Oct;26(5):426-30. doi: 10.3109/09546634.2015.1021238. Epub 2015 Apr 20.


Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with cutaneous hyper-reactivity to environmental triggers, and is characterized by pruritic eczematous skin lesions. Recent insights into the pathophysiology of AD point to the important role that abnormal barrier permeability plays, which leads to compromised hydration, common micro-organismal colonization and immune dysregulation. Current treatment strategies for AD, such as topical corticosteroids and moisturizers, control the disease symptom's severity and duration. KAM-3008 is a novel, barrier-based, steroid-free, topical cream indicated for the relief of symptoms associated with AD. In addition to moisturizing and emollient ingredients, several herbal extracts have been incorporated into the formulation to enhance its anti-allergic and anti-inflammatory properties.

Methods: In this study, the safety and efficacy of KAM-3008 body cream in relieving the symptoms of AD in adult subjects after 7, 14 and 21 days of treatment were investigated using the transepidermal water loss (TEWL), skin hydration and scoring atopic dermatitis (SCORAD) measurements.

Results and conclusions: Based on both the quantitative TEWL and qualitative SCORAD assessments, we found that KAM-3008 body cream is a safe, well-tolerated and efficacious stand-alone treatment for the relief of AD symptoms.

Keywords: Anti-allergic; SCORAD; anti-oxidant; atopic dermatitis; eczema; herbal extracts; transepidermal water loss.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Adult
  • Aged
  • Anti-Allergic Agents / administration & dosage
  • Anti-Allergic Agents / therapeutic use*
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Antioxidants
  • Chronic Disease
  • Dermatitis, Atopic / drug therapy*
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / therapeutic use*
  • Eczema / drug therapy
  • Emollients / administration & dosage
  • Emollients / therapeutic use*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Plant Extracts / administration & dosage
  • Plant Extracts / therapeutic use
  • Skin / drug effects
  • Skin / pathology
  • Skin Diseases / drug therapy
  • Steroids
  • Treatment Outcome
  • Young Adult


  • Anti-Allergic Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Dermatologic Agents
  • Emollients
  • Plant Extracts
  • Steroids