Thalamic and extrathalamic mechanisms of consciousness after severe brain injury

Ann Neurol. 2015 Jul;78(1):68-76. doi: 10.1002/ana.24423. Epub 2015 May 4.


Objective: What mechanisms underlie the loss and recovery of consciousness after severe brain injury? We sought to establish, in the largest cohort of patients with disorders of consciousness (DOC) to date, the link between gold standard clinical measures of awareness and wakefulness, and specific patterns of local brain pathology-thereby possibly providing a mechanistic framework for patient diagnosis, prognosis, and treatment development.

Methods: Structural T1-weighted magnetic resonance images were collected, in a continuous sample of 143 severely brain-injured patients with DOC (and 96 volunteers), across 2 tertiary expert centers. Brain atrophy in subcortical regions (bilateral thalamus, basal ganglia, hippocampus, basal forebrain, and brainstem) was assessed across (1) healthy volunteers and patients, (2) clinical entities (eg, vegetative state, minimally conscious state), (3) clinical measures of consciousness (Coma Recovery Scale-Revised), and (4) injury etiology.

Results: Compared to volunteers, patients exhibited significant atrophy across all structures (p < 0.05, corrected). Strikingly, we found almost no significant differences across clinical entities. Nonetheless, the clinical measures of awareness and wakefulness upon which differential diagnosis rely were systematically associated with tissue atrophy within thalamic and basal ganglia nuclei, respectively; the basal forebrain was atrophied in proportion to patients' response to sensory stimulation. In addition, nontraumatic injuries exhibited more extensive thalamic atrophy.

Interpretation: These findings provide, for the first time, a grounding in pathology for gold standard behavior-based clinical measures of consciousness, and reframe our current models of DOC by stressing the different links tying thalamic mechanisms to willful behavior and extrathalamic mechanisms to behavioral (and electrocortical) arousal.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Atrophy
  • Awareness / physiology*
  • Basal Forebrain / pathology
  • Basal Forebrain / physiopathology
  • Basal Ganglia / pathology
  • Basal Ganglia / physiopathology
  • Brain / pathology*
  • Brain / physiopathology
  • Brain Injuries / complications
  • Brain Injuries / pathology*
  • Brain Injuries / physiopathology
  • Brain Mapping
  • Brain Stem / pathology
  • Brain Stem / physiopathology
  • Case-Control Studies
  • Coma / etiology
  • Coma / pathology*
  • Coma / physiopathology
  • Consciousness / physiology*
  • Consciousness Disorders / etiology
  • Consciousness Disorders / pathology*
  • Consciousness Disorders / physiopathology
  • Cross-Sectional Studies
  • Female
  • Hippocampus / pathology
  • Hippocampus / physiopathology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Persistent Vegetative State / etiology
  • Persistent Vegetative State / pathology
  • Persistent Vegetative State / physiopathology
  • Severity of Illness Index
  • Thalamus / pathology
  • Thalamus / physiopathology
  • Wakefulness / physiology*
  • Young Adult