Risk-based Individualisation of Target Haemoglobin in Haemodialysis Patients With Renal Anaemia in the post-TREAT Era: Theoretical Attitudes Versus Actual Practice Patterns (MONITOR-CKD5 Study)

Int Urol Nephrol. 2015 May;47(5):837-45. doi: 10.1007/s11255-015-0970-8. Epub 2015 Apr 17.


Purpose: Data from an ongoing European pharmacoepidemiological study (MONITOR-CKD5) were used to examine congruence between physician-reported risk-based individualisation of target haemoglobin (Hb) and the actual Hb targets set by these physicians for their patients, as well as actual Hb levels in their patients.

Methods: Physician investigators participating in the study completed a questionnaire about their anaemia practice patterns and attitudes post-TREAT at the start of the study (T1) and in summer 2013 (T2). These data were compared with the Hb targets identified at baseline for actual patients (n = 1197) enrolled in the study. Risk groups included presence/absence of hypertension, diabetes, cardiovascular complications, history of stroke, history of cancer, and age/activity level (elderly/inactive or young/active).

Results: At each time point, more than three quarters of physicians responded that results from the TREAT study, in patients not on dialysis, have influenced their use of erythropoiesis-stimulating agents in patients on haemodialysis. At T1, there was a clear difference in physician-reported (theoretical) target Hb levels for patients across the different risk groups, but there was no difference in patients' actual Hb levels across the risk groups. A similar disparity was noted at T2.

Conclusions: Physicians' theoretical attitudes to anaemia management in patients on haemodialysis appear to have been influenced by the results of the TREAT study, which involved patients not on dialysis. Physicians claim to use risk-based target Hb levels to guide renal anaemia care. However, there is discrepancy between these declared risk-based target Hb levels and actual target Hb levels for patients with variable risk factors.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Age Factors
  • Anemia / blood
  • Anemia / drug therapy*
  • Anemia / etiology
  • Attitude of Health Personnel*
  • Comorbidity
  • Diabetes Mellitus / epidemiology
  • Female
  • Hematinics / adverse effects
  • Hematinics / therapeutic use*
  • Hemoglobins / metabolism*
  • Humans
  • Hypertension / epidemiology
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / epidemiology*
  • Kidney Failure, Chronic / therapy
  • Male
  • Middle Aged
  • Motor Activity
  • Neoplasms / epidemiology*
  • Patient Care Planning
  • Practice Guidelines as Topic
  • Practice Patterns, Physicians'*
  • Precision Medicine
  • Renal Dialysis / adverse effects
  • Risk Factors
  • Stroke / epidemiology


  • Hematinics
  • Hemoglobins