Extracellular matrix-inspired growth factor delivery systems for bone regeneration

Adv Drug Deliv Rev. 2015 Nov 1;94:41-52. doi: 10.1016/j.addr.2015.04.007. Epub 2015 Apr 17.

Abstract

Growth factors are very promising molecules to enhance bone regeneration. However, their translation to clinical use has been seriously limited, facing issues related to safety and cost-effectiveness. These problems derive from the vastly supra-physiological doses of growth factor used without optimized delivery systems. Therefore, these issues have motivated the development of new delivery systems allowing better control of the spatiotemporal release and signaling of growth factors. Because the extracellular matrix (ECM) naturally plays a fundamental role in coordinating growth factor activity in vivo, a number of novel delivery systems have been inspired by the growth factor regulatory function of the ECM. After introducing the role of growth factors during the bone regeneration process, this review exposes different issues that growth factor-based therapies have encountered in the clinic and highlights recent delivery approaches based on the natural interaction between growth factor and the ECM.

Keywords: Bone morphogenetic protein; Clinical translation; Controlled delivery; Extracellular matrix; Fibroblast growth factor; Integrins; Platelet-derived growth factor; Vascular endothelial growth factor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bone Morphogenetic Proteins / administration & dosage
  • Bone Morphogenetic Proteins / pharmacology*
  • Bone Regeneration / physiology*
  • Delayed-Action Preparations
  • Drug Delivery Systems / methods*
  • Extracellular Matrix / metabolism*
  • Fibroblast Growth Factors / administration & dosage
  • Fibroblast Growth Factors / pharmacology
  • Humans
  • Inflammation / physiopathology
  • Integrins / metabolism
  • Intercellular Signaling Peptides and Proteins / administration & dosage
  • Intercellular Signaling Peptides and Proteins / pharmacology*
  • Platelet-Derived Growth Factor / administration & dosage
  • Platelet-Derived Growth Factor / pharmacology
  • Vascular Endothelial Growth Factor A / administration & dosage
  • Vascular Endothelial Growth Factor A / pharmacology

Substances

  • Bone Morphogenetic Proteins
  • Delayed-Action Preparations
  • Integrins
  • Intercellular Signaling Peptides and Proteins
  • Platelet-Derived Growth Factor
  • Vascular Endothelial Growth Factor A
  • Fibroblast Growth Factors