Systemic effects of gut microbiota and its relationship with disease and modulation

BMC Immunol. 2015 Mar 26;16:21. doi: 10.1186/s12865-015-0083-2.


The gut microbiota makes up the majority of the human bacterial population, and although the gut microbiota resides in the intestines, it is able to exert systemic effects. Therefore, many diseases and conditions could be impacted by the gut microbiota when its composition is imbalanced, otherwise known as dysbiosis. However, apart from understanding the illnesses, we must also try to understand the intestinal flora itself to move forward and develop potential treatments.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / therapy*
  • Dysbiosis / immunology*
  • Fecal Microbiota Transplantation
  • Gastrointestinal Microbiome / immunology*
  • Humans
  • Intestinal Mucosa / immunology*
  • Intestinal Mucosa / microbiology
  • Mental Disorders / immunology
  • Mental Disorders / therapy*
  • Neoplasms / immunology
  • Neoplasms / therapy*
  • Prebiotics
  • Probiotics / therapeutic use
  • Synbiotics


  • Prebiotics