Strategies intended to address vaccine hesitancy: Review of published reviews

Vaccine. 2015 Aug 14;33(34):4191-203. doi: 10.1016/j.vaccine.2015.04.041. Epub 2015 Apr 18.


When faced with vaccine hesitancy, public health authorities are looking for effective strategies to address this issue. In this paper, the findings of 15 published literature reviews or meta-analysis that have examined the effectiveness of different interventions to reduce vaccine hesitancy and/or to enhance vaccine acceptance are presented and discussed. From the literature, there is no strong evidence to recommend any specific intervention to address vaccine hesitancy/refusal. The reviewed studies included interventions with diverse content and approaches that were implemented in different settings and targeted various populations. Few interventions were directly targeted to vaccine hesitant individuals. Given the paucity of information on effective strategies to address vaccine hesitancy, when interventions are implemented, planning a rigorous evaluation of their impact on vaccine hesitancy/vaccine acceptance will be essential.

Keywords: Interventions; Literature reviews; Strategies; Vaccination hesitancy; Vaccine acceptance; Vaccine hesitancy; Vaccine refusal; Vaccine uptake.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Health Knowledge, Attitudes, Practice*
  • Humans
  • Parents / psychology
  • Patient Acceptance of Health Care*
  • Patient Compliance
  • Public Health
  • Treatment Refusal
  • Vaccination
  • Vaccines*


  • Vaccines