Genetics and hepatitis C: it's good to be 'CC'

Jose Mari Parungao; Ibrahim A Hanouneh; Binu John; Naim Alkhouri; Nizar N Zein

doi:10.3949/ccjm.82a.14004

Genetics and hepatitis C: it's good to be 'CC'

Cleve Clin J Med. 2015 Feb;82(2):97-104. doi: 10.3949/ccjm.82a.14004.

Authors

Jose Mari Parungao¹, Ibrahim A Hanouneh^{2

3}, Binu John^{2

3}, Naim Alkhouri⁴, Nizar N Zein^{2

5}

Affiliations

¹ Department of Gastroenterology, Providence Hospital and Medical Centers, Southfield, MI, USA.
² Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic.
³ Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
⁴ Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA.
⁵ Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA. E-mail: zeinn@ccf.org.

PMID: 25897598
DOI: 10.3949/ccjm.82a.14004

Abstract

The interleukin-28B (IL28B) gene contains a single-nucleotide polymorphism at location rs12979860 that affects both the natural history of hepatitis C virus infection and the patient's response to treatment, particularly interferon-based regimens with or without protease inhibitors.

Publication types

Review

MeSH terms

DNA / genetics*
Genetic Markers
Hepatitis C, Chronic* / genetics
Hepatitis C, Chronic* / metabolism
Hepatitis C, Chronic* / virology
Humans
Interferons
Interleukins / genetics*
Interleukins / metabolism
Polymorphism, Single Nucleotide

Substances

Genetic Markers
interferon-lambda, human
Interleukins
DNA
Interferons