Therapeutics and vaccines against chikungunya virus

Vector Borne Zoonotic Dis. 2015 Apr;15(4):250-7. doi: 10.1089/vbz.2014.1681.


Currently, there are no licensed vaccines or therapies available against chikungunya virus (CHIKV), and these were subjects discussed during a CHIKV meeting recently organized in Langkawi, Malaysia. In this review, we chart the approaches taken in both areas. Because of a sharp increase in new data in these fields, the present paper is complementary to previous reviews by Weaver et al. in 2012 and Kaur and Chu in 2013 . The most promising antivirals so far discovered are reviewed, with a special focus on the virus-encoded replication proteins as potential targets. Within the vaccines in development, our review emphasizes the various strategies in parallel development that are unique in the vaccine field against a single disease.

Keywords: Antibodies; Antiviral; Attenuated virus; Chikungunya; DNA chimeric viruses; Polymerase; Protease; Vaccine; Virus-like particles.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibodies, Viral / immunology*
  • Antiviral Agents / therapeutic use*
  • Chikungunya Fever / drug therapy
  • Chikungunya Fever / immunology
  • Chikungunya Fever / prevention & control*
  • Chikungunya virus / immunology*
  • Malaysia
  • Viral Proteins / immunology
  • Viral Vaccines / immunology*
  • Virus Replication


  • Antibodies, Viral
  • Antiviral Agents
  • Viral Proteins
  • Viral Vaccines