Long-range neural synchrony in behavior

Annu Rev Neurosci. 2015 Jul 8;38:171-94. doi: 10.1146/annurev-neuro-071714-034111. Epub 2015 Apr 6.


Long-range synchrony between distant brain regions accompanies multiple forms of behavior. This review compares and contrasts the methods by which long-range synchrony is evaluated in both humans and model animals. Three examples of behaviorally relevant long-range synchrony are discussed in detail: gamma-frequency synchrony during visual perception, hippocampal-prefrontal synchrony during working memory, and prefrontal-amygdala synchrony during anxiety. Implications for circuit mechanism, translation, and clinical relevance are discussed.

Keywords: coherence; gamma; hippocampus; oscillations; prefrontal cortex; theta.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amygdala / physiology
  • Animals
  • Anxiety / physiopathology*
  • Brain Mapping / methods
  • Brain Waves / physiology*
  • Gamma Rhythm / physiology
  • Hippocampus / physiology
  • Humans
  • Memory, Short-Term / physiology*
  • Neural Pathways / physiology*
  • Prefrontal Cortex / physiology
  • Visual Perception / physiology*